The embodied approach of human cognition suggests that concepts are deeply dependent upon and constrained by an agent's physical body's characteristics, such as performed body movements. In this study, we attempted to broaden previous research on emotional priming, investigating the interaction of emotions and visual exploration. We used the joystick-based approach-avoidance task to influence the emotional states of participants, and subsequently, we presented pictures of news web pages on a computer screen and measured participant's eye movements. As a result, the (...) number of fixations on images increased, the total dwell time increased, and the average saccade length from outside of the images toward the images decreased after the bodily congruent priming phase. The combination of these effects suggests increased attention to web pages' image content after the participants performed bodily congruent actions in the priming phase. Thus, congruent bodily interaction with images in the priming phase fosters visual interaction in the subsequent exploration phase. (shrink)

This paper throws some light on the nature of argumentation, its use and advantages, within the setting of doctor–patient interaction. It claims that argumentation can be used by doctors to offer patients reasons that work as ontological conditions for enhancing the decision making process, as well as to preserve the institutional nature of their relationship with patients. In support of these claims, selected arguments from real-life interactions are presented in the second part of the paper, and analysed by means of (...) a model of argumentation borrowed from classical rhetoric, and refined according to the modern orientation of the pragma-dialectic approach. (shrink)

This article explores melodrama's capacity to evoke strong emotional responses with a focus on the ending of King Vidor's Stella Dallas. It suggests a consideration of the phenomenological concept of instrument-mediation as coined by Vivian Sobchack as a filmic structure that fosters melodrama's emotional appeal and the spectator's engagement with it. It suggests a self-reflexive element in highly emotional film scenes that inscribes the spectator's subject position into the film, thus enabling the film to impact the spectator's body. This reflection (...) of a spectator's perspective enables and fosters the communication of emotionality. Consequently, instrument-mediation describes one function and strategy of the melodramatic mode. (shrink)

Systems of urban transportation are largely shaped through planning practices. In transport economics, the benefits of infrastructure investments consist mainly of travel time savings calculated using monetary values of time. The economic interpretation of the value of travel time has significantly shaped our urban environment and transportation schemes. However, there is often an underlying assumption of transferability between time and money, which arguably does not sufficiently take into account the specific features of time. In this paper, we analyze the various (...) properties of time as an economic resource using findings in behavioral economics and psychology. Due to limitations in the standard model, it is proposed that an alternative model value should be investigated in which time rather than money is the primary carrier of and the basic features of such a model are outlined. An improved understanding the nature of time as a source of utility puts us in a better position to determine what aspects of time matter. Additionally, the analysis can be applied to further develop modeling where value of time plays a significant role; such as new models for the planning of urban transport. (shrink)

This article describes interactional features of an interrogation method that is used by law enforcement and private security companies in the US known as the ‘soft accusation’ method. We demonstrate how the method, in contrast to the more common ‘story solicitation’ method, makes use of a ‘telling about oneself ’ activity to actually suppress a subject’s talk by setting up and maintaining an exceptionally long turn by the interrogator. This turn not only constrains subjects’ speaking contributions to the issuing of (...) continuers and acknowledgments, and, as such, their opportunities to challenge or resist, but, based as it is on ‘telling about oneself ’, re-organizes the knowledge differential to one in which it is the interrogator rather than the subject who has primary epistemic rights of disclosure. We provide an overview of interactional problems associated with the story solicitation method and then consider how the soft accusation method is designed to counter them, particularly via practices of informing and describing that are associated with the activity of ‘telling about oneself ’. As we show, these practices make use of techniques of elaboration that provide a resource for turn expansion, as well as for seamless topical movement that works to positively align the subject to the interrogator’s talk and, thus, to smooth the interactional pathway to the subject’s admission of guilt. (shrink)

The article engages with the protagonist of The Secret Gospel of Mary Magdalene by Michèle Roberts, first published in 1984 as The Wild Girl. Filipczak discusses scholarly publications that analyze the role of Mary Magdalene, and redeem her from the sexist bias which reduced her to a repentant whore despite the lack of evidence for this in the Gospels. The very same analyses demonstrate that the role of Mary Magdalene as Christ’s first apostle silenced by patriarchal tradition was unique. While (...) Roberts draws on the composite character of Mary Magdalene embedded in the traditional association between women, sexuality and sin, she also moves far beyond this, by reclaiming the female imaginary as an important part of human connection to the divine. At the same time, Roberts recovers the conjunction between sexuality and spirituality by framing the relationship of Christ and Mary Magdalene with The Song of Songs, which provides the abject saint from Catholic tradition with an entirely different legacy of autonomy and expression of female desire, be it sexual, maternal or spiritual. The intertext connected with The Song of Songs runs consistently through The Secret Gospel of Mary Magdalene. This, in turn, sensitizes the readers to the traces of the Song in the Gospels, which never quote from it, but they rely heavily on the association between Christ and the Bridegroom, while John 20 shows the encounter between the risen Christ and Mary Magdalene in the garden whose imagery is strongly suggestive of the nuptial meeting in The Song of Songs. (shrink)

The feasibility of posthumous reproduction when the surviving partner is female has brought to light many ethical, moral, social, and legal issues. This review aims to summarize these issues and to assist clinicians who may be faced with such requests. A question list, used for health technologies assessment, was utilized in a question-answer approach as the review methodology. Of the 1,208 publications identified through a comprehensive literature search in biomedical, psychological, and ethical databases, 31 articles included arguments related to one (...) or more questions from the predefined question set. Key stakeholders identified include the deceased, the requesting party, the resultant child, the physician, and society. Key ethical issues relevant to posthumous reproduction include the four traditional pillars of medical ethics—autonomy, beneficence, nonmaleficence, justice—as well as the stakeholders’ rights and sociocultural attitudes. The ethical framework formulated by these issues has been incorporated in a clinical ethics decision-making tool that could prove useful to clinicians and decision makers. (shrink)

One of St. Augustine's earliest prayers after his conversion was a prayer to understand himself and to discover God. He came to realize that all humans follow more or less the same path of discovery, a path that begins in darkness and ends in Wisdom. Most of us never achieve the perfection of wisdom, but in the meantime we can be certain that we are showing our love for God by reaching out to our fellow human beings. In such loving (...) we can be confident that God is close to us. (shrink)

Double‐checking one's reasoning is a perfectly normal way of responding to a disagreement between peers. I argue that conciliationist approaches lack the resources to accommodate this phenomenon adequately. On the one hand, conciliationists cannot claim that double‐checking is a rationally impermissible response to disagreement because a compelling case for its permissibility appeals to arguments analogous to those often used by conciliationist in favour of their own view. On the other, they lack the resources to accommodate double‐checking as a rationally permissible (...) response to disagreement. To show this, I draw a distinction between strong and moderate versions of conciliationism. The strong version accepts, whereas the moderate version rejects, that the conciliatory obligation exhausts the rational requirements engendered by disagreements. Strong conciliationists cannot explain the motivation for someone to double‐check if they have followed the conciliationists advice. Moderate conciliationists who try to make space for double‐checking are forced to concede that disputants can respond rationally to disagreement without lowering their confidence in the disputed belief. (shrink)

Academic debates are so frequent and omnipresent in most disciplines, particularly the social sciences and humanities, it seems obvious that disagreements are bound to occur. The aim of this paper is to show that whereas the agent who perceives his/her contribution as being misunderstood locates the origin of the communication problem on the side of the receiver who "misinterprets" the text, the emitter is in fact also contributing to the possibility of this misunderstanding through the very manner in which his/her (...) text is written. In other words, I propose a symmetric approach to understanding misunderstandings: taking simultaneously into account the position of the reader in the scientific field and the structure of the texts of the writers. The paper thus proposes to complement the sociological analysis of controversies in a scientific field with the close reading of texts, a practice usually found in studies of argumentation, in order to explain the occurrence of misunderstandings. The debate surrounding the charge of "relativism" among sociologists of scientific knowledge provides us with a case study to analyse in detail the argumentative context of misunderstanding. (shrink)

The corporate social responsibility literature recognizes that firms’ existing CSR reputation can serve as a safeguard from the impact of reputation-damaging events on a firm’s social legitimacy. However, the literature has yet to focus on the extent to which CSR activities can help mitigate such damage, post-event. This article examines how a firm’s social actions following a product recall facilitate the recovery of its diminished social legitimacy. We test our predictions using a sample of 197 product recalls involving 168 publicly (...) traded corporations from 1999 to 2009 and demonstrate that the speed of the CSR response, the frequency of CSR activities, and the intensity of CSR activities have a significant effect on firm recovery following crisis. The effects were most pronounced in instances where the magnitude of the recall was most severe. The visibility of the recall has a limited impact on post-event recovery. We discuss our contributions to research on strategic CSR and recovery. (shrink)

This paper argues for a deflationary account of trying on which ‘x tried to ϕ’ abbreviates ‘x did something with the intention of ϕ-ing’, where ‘did something’ is treated as a schematic verb. On this account, tryings are not a distinctive sort of episode present in some or all cases of acting. ‘x tried to ϕ’ simply relates some doing of x’s to a further aim x had, which may or may not have been achieved. Consequently, the analysis of ‘x (...) tried to ϕ’ adds nothing to our basic understanding of the nature of action or agency. The account handles examples of naked trying, trying without acting – for example, trying but failing to move when paralyzed – by construing ‘did something’ as a schematic verb for a broader class of purposive events than actions, subsuming inter alia the formation of intentions-in-action. It gives a technical sense to ‘doing with the intention of ϕ-ing’ so that it includes any doing that can be construed as for the purpose of executing the intention of ϕ-ing. This subsumes as a limiting case the formation of an intention-in-action to ϕ, which is for the purpose of executing that very intention. (shrink)

Kazuo Ishiguro’s 2005 science fiction novel Never Let Me Go and Mark Romanek’s 2010 film adaptation depict an alternate past in which human longevity is achieved by harvesting organs from clones. The clones seem ostensibly human and yet are considered nonhuman “creatures.” The book and film use differing strategies to align the nonhuman clones with nonhuman animals, a connection that is often ambivalent and contradictory. This article argues that through narrational and audio-visual address respectively, the reader and viewer are encouraged (...) to bear witness from a liminal, creaturely position. (shrink)

Scientists have been arguing for more than 25 years about whether it is a good idea to collect voucher specimens from particularly vulnerable biological populations. Some think that, obviously, scientists should not be harvesting organisms from, for instance, critically endangered species. Others think that, obviously, it is the special job of scientists to collect precisely such information before any chance of retrieving it is forever lost. The character, extent, longevity, and span of the ongoing disagreement indicates that this is likely (...) to be a hard problem to solve. Nonetheless, the aim of this paper is to help field biologists figure out what do to when collecting a voucher specimen risks extinction. Here I present and assess varying practices of specimen collection for both extant and extinct species in order to compare and contrast cases where extinction risk both is and is not a problem. When it comes to taking vouchers from extant species at some risk of extinction, I determine that those advocating for conservative approaches to collection as well as those advocating for liberal information-gathering practices have good reasons to assess things in the way they each do. This means that there is unlikely to be a decisive, one-size-fits-all response to this problem. Still, progress can be made. We can acknowledge the risks of proceeding in either manner, as well as the uncertainty about how best to proceed. We can proceed as thoughtfully as possible, and be ready to articulate a rationale for whichever procedure is used in any particular case. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Let Me Pay Taxes!Alessia MinicozziThe first memory I have of knowing that I was different was when I was five years old and a caseworker entered my house to verify that I existed.At the age of one and a half, I was diagnosed with a chronic disease called Spinal Muscular Atrophy, Type II (SMA). This left me in need of constant care and, at times, hospitalizations. My whole life, (...) I’ve been confined to a wheelchair, and the disease has always affected me profoundly, on a physical and mental level. I have limited range of motion and strength in my arms, muscle weakness affects my speech and breathing, and, like a monkey on my back, SMA has been a constant reminder of my fragility and mortality.In order to comply with Pennsylvania’s disability requirements, a state–appointed caseworker had to make regular home visits to make sure my needs were being met under my parents’ care and that my parents were not lying about my medical needs. These visits would leave me confused and annoyed. I still remember the events that took place the first time a caseworker entered my house and the emotional impact it had on me.The time read 8:09 a.m. on my white clock radio. I wore my favorite pink satin nightgown. My mother came to lift me out of bed and enclose me in my robe. She whispered in my ear that a gentleman was here to meet me—he’d arrived early—and he wanted to ask me some questions. As my mother carried me down the flight of stairs and sat me in my wheelchair, I felt the man’s eyes on our every move. This strange man sat with a scrutinizing look and asked me if I live in this house and do I normally wake up so late? I quickly turned to my [End Page 210] mother and gave her a perplexed stare. Why was this person here at all, and what right did he have to inquire about me like this?Later, my mother would explain that the man was there to make sure that she was not lying when she asked the government for money to care for me. I endured countless visits from that caseworker over many years. Finally, I asked my mother, “When is this man going to stop visiting me and asking me the same questions?” She looked at me and tenderly replied that when my father finished his residency program, then we would have enough money to pay for all my care. I accepted this response and continued playing with my Barbie. Two years later, my father completed his residency program and the visits from the caseworker stopped.In eighth grade, I left an all disabled school and enrolled in a mainstream public school, which seemed odd to me. I asked my parents why the change in schools? My parents explained that they will not live forever and in order for me to live outside an institution, I will need a salary that is above average to pay for personal care. They went on to explain that the only way to accomplish this goal is to succeed in school and to perform better than everyone else. They informed me that because I use a wheelchair, prospective employers will view me as daunting and they may be less likely to hire me. They stressed that the only way to stand out above other non–disabled candidates is to excel in an academic environment. Mom and Dad have always ended the conversation by reassuring me that as long as they are alive, they will make sure I accomplish everything I set out to achieve and that I never feel alone.Since that conversation over twenty years ago, I had only one goal in mind: employment. The possibility of being institutionalized has always been my motivation for persevering through late nights of writing papers and studying for exams. As promised, my parents were the ones who proofread my papers and stayed up with me in order to help me to bed once I was done. When I graduated from the University of... (shrink)

This article aims to explore Kazuo Ishiguro’s Never Let Me Go within the Foucauldian theoretical framework in order to analyse the manifold biopolitical issues, namely cloning, by stretching the discourse to a speculative, dystopian posthuman scenario wherein the dominant, privileged, affluent human society replenishes them by incorporating bio-matter from the clones. The article also proposes to unfold the myriad ways the institutions, namely Hailsham and recovery centres in the novel, exercise power and execute power relations with the clones. It describes (...) the way these institutions turn out to be what Foucault calls the regimes of truth and how the clones choose to remain docile to the institutional power, and consequently, they turn out to be rich sites for both medical gaze and disciplinary gaze. Nevertheless, the article also details the procedures by which the bizarre truth of organ donation of the clones is buried under the technical discourse of good work. (shrink)

ZusammenfassungIm Spielfilm Never Let Me Go werden Klone als vulnerable und heteronome Individuen dargestellt, die zur anonymen Organspende gezwungen werden. In diesem Beitrag wird die Darstellung dieser Figuren in ihrer individuellen Entwicklung und gesellschaftlichen Sozialisation unter der Frage untersucht, welche Bezüge sich zu bioethischen Aspekten ergeben. Die Klone befinden sich in einer Situation der „privilegierten Deprivation“: Aus Sicht der Zuschauer sind sie sozial benachteiligt und können sich nicht zu komplett autonomen Wesen entwickeln, aber aus ihrer eigenen Perspektive sind sie im (...) dystopischen System immer noch „privilegiert“. Wir argumentieren, dass dieser Film auf symbolische Weise diejenigen Individuen fokussiert, die vom medizinischen Fortschritt nicht profitieren oder die nicht genügend Handlungsspielraum haben, um sich gegen geltende Praxen zu positionieren. Filme wie Never Let Me Go können deshalb ein Beitrag sein, um die Perspektive marginalisierter Personen im medizinischen System einzunehmen. (shrink)

Miranda Fricker distinguishes two senses in which testimonial injustice is epistemic. In the primary sense, it is epistemic because it harms the victim as a giver of knowledge. In the secondary sense, it is epistemic, more narrowly, because it harms the victim as a possessor of knowledge. Her characterization of testimonial injustice has raised the following objection: testimonial injustice is not always an epistemic injustice, in the narrow, secondary sense, as it does not always entail that the victim is harmed (...) as a knowledge-possessor. By adopting a perspective based on Robert Brandom's normative expressivism, we respond to this objection by arguing that there is a close connection, conceptual and constitutive rather than merely causal, between the primary and the secondary epistemic harms of testimonial injustice, such that testimonial injustice always involves both kinds of epistemic harm. We do so by exploring the logic and functioning of belief and knowledge ascriptions in order to highlight three ways in which the secondary epistemic harm caused by testimonial injustice crystallizes: it undermines the epistemic agency of the victim, the epistemic friction necessary for knowledge, and the possibility of occupying particular epistemic nodes. (shrink)

This article examines the discursive uses of frequent response initiators by Republican and Democratic presidential candidates in the genre of televised US primary debates. Ten full transcripts of debates held between February and April 2016 are investigated from the perspectives of political discourse studies and conversation analysis. It is shown that the response initiators well, first of all, look, you know and let me speech act verb fulfill specific discursive functions in competitive media discourse. On the textual level, candidates exert (...) power and control by negotiating turn-taking processes and managing the information flow. On the interactional level, competitors use response initiators to frame themselves as likable and competent personas, to establish common ground with voters and to enhance negative perceptions of opponents. Conclusively, in the multilogue of election debates, response initiators significantly contribute to the construction of individual preferability. (shrink)

( http://philpapers.org/profile/112741 )"Let generation know to procure the love, the concept, knowledge and ideas with thoughts they are acquiring on versatile English Language, instead of making themselves to be felt dealing with only burden." -/- I too realize, -/- "Literature is not merely going through a book, It is the moment of definition of per feeling that : I am acquiring through an imagery.".

(http://philpapers.org/profile/112741 ) [https://plus.google.com/108060242686103906748/posts/cwvdB6mK3J6 ] "Let generation know to procure the love, the concept, knowledge and ideas with thoughts they are acquiring on versatile English Language, instead of making themselves to be felt dealing with only burden." -/- I too realize, -/- "Literature is not merely going through a book, It is the moment of definition of per feeling that : I am acquiring through an imagery.".

Kazuo Ishiguro’s book Never Let Me Go is a thoughtful and provocative exploration of what it means to be human. Drawing on insights from the hermeneutic-phenomenology of Martin Heidegger, I argue that the movement of Ishiguro’s story can be understood in terms of actualising the human potential for autonomous action. Liberal theories take autonomy to be concerned with analytically and ethically isolatable social units directing their lives in accordance with self-interested preferences, arrived at by means of rational calculation. However, I (...) argue that such theories are simplistic abstractions from our human-life world, distorting the fundamental embodied, embedded, and relational nature of autonomy. When we attend closely to our concrete, lived existence we see instead that autonomy is about responding appropriately to others with whom we share a world. As we follow the path of Ishiguro’s central character Kathy H., we are shown how an awareness and acceptance of our existential finitude as precarious and fallible creatures is necessary for guiding such appropriate interactions. As Kathy grows and is affirmed into her life-world, which grounds and supports her Being, she moves from heteronomy to autonomy; from being moved by external laws to embodying those laws, thereby becoming autonomous. This is exemplified by her appropriation of the carer role, through which she responds in a fitting way to those with whom she shares her world, bearing the weight of and dwelling responsibly within our human condition. (shrink)

This reflection essay examines the poem “My own heart,” one of Gerard Manley Hopkins’ Terrible Sonnets, to inspect Hopkins’ articulation of his changed attitude in how he talks to himself. After introducing the concept of self-talk as it figures in Psalms 42 and 43 and identifying its place in the Ignatian tradition, this essay offers a close reading of the poem to see how Hopkins learns to talk to himself more graciously during the spiritual phase of desolation. His desire to (...) “have more pity on” himself expresses a desire to surrender to God's compassion and timing. Hopkins’ ability to render this human experience of struggle and surrender, without any real change in circumstance or without the arrival of consolation, helps us understand both why this faculty of gracious self-talk is so life giving and how we can practice it ourselves. (shrink)

Interrogating the oft-stated emotion of ‘guilt’ amongst young female activists, I develop a theoretical account of why young women seem to be more burdened with such negative emotions than young men. Drawing on feminist theorising, I posit that young women’s emotional accounts of activist work highlight the retraditionalisation of gender under neoliberal modernity. I provide evidence of the gender-differentiated demands that heightened forms of reflexivity place on women, young women in particular. I then consider alternative conceptions of politics, grounded in (...) the work of Hannah Arendt, and extending my own earlier work on relational agency (Kennelly, 2009). Drawing on phenomenology to offer an account of political engagement grounded in the lived experiences of activists, I suggest that social movements might be bolstered through a deepened understanding of the role played by webs of relations and world-building practices, without losing sight of the gendered implications of such a turn. (shrink)

§1. Introduction. I dedicate this essay to the two-dozen-odd people whose refutations of Cantor's diagonal argument have come to me either as referee or as editor in the last twenty years or so. Sadly these submissions were all quite unpublishable; I sent them back with what I hope were helpful comments. A few years ago it occurred to me to wonder why so many people devote so much energy to refuting this harmless little argument—what had it done to make them (...) angry with it? So I started to keep notes of these papers, in the hope that some pattern would emerge.These pages report the results. They might be useful for editors faced with similar problem papers, or even for the authors of the papers themselves. But the main message to reach me is that there are several points of basic elementary logic that we usually teach and explain very badly, or not at all.In 1995 an engineer named William Dilworth, who had published a refutation of Cantor's argument in the Transactions of the Wisconsin Academy of Sciences, Arts and Letters, sued for libel a mathematician named Underwood Dudley who had called him a crank. (shrink)

In this paper we examine some of the astrological content in Proclus' exegesis of the 'nuptial number' in Republic 545d, ff. The downfall of the best city-state is said by Socrates to be due to the fact that the Guardians, for all their wisdom, make a mistake about the timing of the breeding of future rulers and this mistake is somehow due to perception. We argue that Proclus' Republic Commentary is best understood as supposing that the Guardians are highly capable (...) astrologers who can -- up until one fateful day -- reliably hit the astrological trifecta: they combine conception astrology with natal and katarchic astrology. The marriage festivals are timed so that future Guardians are conceived under the right stars, with pregnancies of the right duration, and are born under the right stars, with guardian daemons whose names and natures are known through an astrologically-oriented theurgic practice. All this (and more) Proclus took to be hinted at through Socrates' opaque specification of the marriage number. (shrink)

A crucial challenge for critical disability studies is developing an argument for why disabled people should inhabit our democratic, shared public sphere. The ideological and material separation of citizens into worthy and unworthy based on physiological variations imagined as immutable differences is what I call eugenic world building. It is justified by the idea that social improvement and freedom of choice require eliminating devalued human traits in the interest of reducing human suffering, increasing life quality, and building a more desirable (...) citizenry. In this essay, I outline the logic of inclusive and eugenic world building, define and explain the role of the "normate" in eugenic logic, and provide a critical disability studies reading of the 2005 novel Never Let Me Go by Kazuo Ishiguro and its 2010 film adaptation. I argue that the ways of being in the world we think of as disabilities must be understood as the natural variations, abilities, and limitations inherent in human embodiment. When this happens, disability will be understood not as a problem to be eliminated but, rather, as a valid way of being in the world that must be accommodated through a sustaining and sustainable environment designed to afford access for a wide range of human variations. (shrink)

In the film Never Let Me Go, clones are forced to donate their organs anonymously. As a work of fiction, this film can be regarded as a negotiation of limited agency, since the clones are depicted as vulnerable individuals. Thereby, it evokes a confrontation with underprivileged positions in technocratic societies, encouraging the audience to take the perspective of the marginalised. The clones are situated in ‘privileged deprivation’; from the audience’s point of view, they are unable to evolve into autonomous agents—but (...) from their own perspective within the dystopian system, they are still ‘privileged’. In this paper, we analyse the depiction of the clones’ personal development. Further, we examine references to bioethical aspects as well as technologies that affect the human body both on a micro and macro level—cloning and its impact on the human embryo and organ donation practised on the full-grown human body. We argue that this film as a reference for the discussion in popular culture focuses on individuals who do not profit from modern technical progress or do not have enough agency to refuse it. To make this point, we analyse the film’s fictional story, set in a form of alternate history, as a negotiation of a historical context which brings out the idea of neglected voices. (shrink)

This essay examines debates over alternative ethical formulations that break from the Kantian model through contemporary fiction—Kiran Desai’s The Inheritance of Loss (2006), Kazuo Ishiguro’s Never Let Me Go (2005) and Zadie Smith’s On Beauty (2005). The essay returns to the theory, the ethics of care, put forward by Carol Gilligan in In a Different Voice (1982), which has regained significance in the context of questions surrounding care in contemporary ethical thinking. While the three novels are concerned with ideas of (...) care, beauty, justice and the tyranny of the mainstream, this essay examines particular themes in particular texts which suggest that ideas with otherwise subversive potential—like care or beauty or justice—lose their radicalism when they are incorporated within the impersonal, masculinist mainstream. Carol Gilligan’s feminine ethics of care, with its respect for the particular, is not only still important as the stimulus to thinking about alternatives to overarching ethical discourses, but it could also re-confer these concepts of care, beauty and justice their revolutionary potential. (shrink)

Understanding the impact of the p53 tumor suppressor pathway on the regulation of genome integrity, cancer development, and cancer treatment has intrigued scientists and clinicians for decades. It appears that the p53 pathway is a central node for nearly all cell stress responses, including: gene expression, DNA repair, cell cycle arrest, metabolic adjustments, apoptosis, and senescence. In the past decade, it has become increasingly clear that p53 function is directly regulated by poly(ADP‐ribose) polymerase‐1 (PARP‐1), a nuclear enzyme involved in DNA (...) repair signaling. Here, we will discuss the impact of PARP‐1 on p53 function, along with a recently described novel role for the reciprocal regulation of p53 regulated, PARP‐1 dependent necrosis following DNA damage. (shrink)

Several paleontologists have recently challenged the explanatory adequacy of the modern synthetic theory of evolution. Their position is that, contrary to the prevailing view that evolutionary change is gradual, the fossil record manifests long periods of species stasis punctuated by periods of rapid species formation. And, they argue, this punctuated equilibria pattern challenges the gradualist, adaptationist and extrapolationist assumptions of the modern synthetic theory of evolution and supports a hierarchical, non-extrapolationist view of evolution. In this paper I argue that the (...) challenge rests on an inadequate characterization of the modern synthetic theory and that, even accepting punctuated equilibria and an irreducible evolutionary hierarchy, the modern synthetic theory is adequate to explain evolutionary change at all levels of the hierarchy. (shrink)

Previous theoretical accounts have predicted that warfare and intergroup conflict are environmental factors that contribute to the emergence of a fast life-history strategy. However, this assumption has never been directly empirically tested. We examined youth who grew up in a territory that experienced violent intergroup conflict and compared them with a control group on various life-history measures: age of first sexual intercourse, mating behavior, desired timing of marriage and first reproduction and desired number of children. We also measured other characteristics (...) to explore the congruence between them and exposure to conflict. Participants from the postconflict society showed indications of faster life-history strategy: greater mating effort, a tendency to marry and have their first child sooner, and a larger desired number of children. Furthermore, interactions between exposure to conflict and participants’ sex were found: females from a postconflict society want to have their child earlier, and males have elevated short-term mating success. Finally, the exposure to violent conflict turned out to have congruent effects with economic poverty but not troublesome family relations. The findings are in accordance with life-history theory and show the adaptiveness of human behavior related to fitness optimization in hostile and dangerous environments. (shrink)